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KMID : 0387719960070010023
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Korean Journal of Blood Transfusion
1996 Volume.7 No. 1 p.23 ~ p.26
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Evaluation of the Use of Rh(D) control Test in Rh(D) Typing
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Abstract
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Clinically, the Rh blood group system is important since Rh antibodies are readily induced by transfusion or pregnancy in individuals negative for the antigen and may cause hemolytic reactions or hemolytic disease of the newborn Since the D
antigen is strongly immunogenic, donors and patients are routinely typed for D status and patients are generally given D compatible blood. But under several circumstances such as spontaneous agglutination of red blood cells coated with immunoglobulin, antisera with additives may cause false positive results in test using high-protein reagents. And factors in the patient’s own serum may also affect the test, since unwashed red blood cells suspended in their own serum or plasma are frequently tested. Therefore, manufacturers and American Association of Blood Banks (AABB) recommend that the Rh(D) control test with Rh(D) control reagent which contains the same additive present in high-protein anti-D except for the anti-D. This study was undertaken to evaluate the usefulness of the Rh(D) control test in Korea where Rh(D) negative population is small. Red blood cells from 1115 in patients and 468 out-patients at Korea University Medical Center were employed in Rh(D) typing and Rh(D) control test in parellel. 1580 cases are Rh(D) positive and 3 cases were Rh(D) negative. No agglutination was observed with Rh(D) control test. Though AABB and manufacturers recommended that the Rh(D) control test should be done in parellel with Rh(D) typing test, the authers concluded that there were no need to run the Rh (D) control test in Korea.
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